The effect of intermittent coronary sinus occlusion on coronary sinus pressure dynamics and coronary arterial flow.

Automatic Computation for Pressure Controlled Intermittent Coronary Sinus Occlusion

Pressure controlled intermittent coronary sinus occlusion (PICSO) has been found to substantially salvage ischemic myocardium. By elevating venous pressure two mechanisms are involved namely the distention of venous vessels inducing mechanotransduction as well as a redistribution of venous flow towards ischemic areas. Mechanotransduction in endothelial cells inducing changes in the ischemic hea...

Intermittent coronary sinus occlusion after coronary arterial ligation results in venous retroperfusion.

Coronary sinus occlusion retards necrosis of ischemic myocardium. To test the hypothesis that coronary sinus occlusion induces retrograde venoarterial flow, the coronary arteriovenous pressure gradient and the coronary arterial oxygen saturation were measured distal to a left anterior descending coronary artery ligature in dogs. In parallel, we constructed a mathematical model of known coronary...

The efficacy of intermittent coronary sinus occlusion in the absence of coronary artery collaterals.

The purpose of this study was to evaluate the efficacy of time-controlled intermittent coronary sinus occlusion (ICSO) in preserving regional and global mechanical function during acute ischemia in an animal preparation without significant arterial collateral vessels. Seventeen (eight control, nine ICSO) swine heart preparations undergoing extracorporeal coronary perfusion in situ were subjecte...

The effect of acute occlusion of the coronary sinus on the coronary circulation.

The changes in the coronary circulation, which are precipitated by the acute occlusion of the coronary sinus, have been investigated. In normal animals, retrograde blood emerging from the peripheral segment of a ligated and transected circumflex coronary artery is small in quantity, and arterial in nature, signifying an insignificant interarterial collateral flow. After the coronary sinus is ar...

The effect of arterialization of the coronary sinus in dogs on mortality following acute coronary occlusion.